Liver function was assessed by measuring aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin, and bile salt excretion in urine. FK506 was administered either systemically alone or in combination with SMT. Male SD rats received a combined liver-kidney transplant. Since inducible nitric oxide synthase (iNOS) is stimulated in the liver in response to FK506, the authors used a novel inhibitor of iNOS, S-methylisothiourea sulfate (SMT), to determine if selective inhibition of iNOS could protect the liver against FK506-induced cholestasis and to assess the mechanism of cholestasis. Recent data indicate that nitric oxide (NO) is involved in the pathogenesis of FK506-induced cholestasis, a common complication of liver transplantation. The immunosuppressant tacrolimus (FK506) causes a number of side effects in liver transplant recipients that can result in graft loss. Autodesk 3ds Max 2019 with Softimage, 978K1.Īutodesk 3ds max 2019, x-force 2019, autocad 2019 with softimage, autodesk 2020, 2020 autocad with softimageSelective inhibition of inducible nitric oxide synthase prevents tacrolimus-induced cholestasis in a rat model of liver transplantation. Download Xforce Keygen 3ds Max 2019 ActivationĪutodesk 3ds Max 2019 with Softimage, 978K1.
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